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© 1981 Oxford University Press

research-article

ANEUPLOIDY IN CULTURED HUMAN LYMPHOCYTES: II. A COMPARISON BETWEEN SENESCENCE AND DEMENTIA

JUDITH M. MARTIN, Research Worker, J.M. KELLETT, Consultant Psychogeriatrician and J. KAHN, Lecturer

Department of Neuropathology, Institute of Psychiatry De Crespigny Park, Denmark Hill, London SE5 8AF
Department of Psychistry, St George's Hospital Medical School Blackshaw Road, London SW17 0QT
Department of Neuropathology, Institute of Psychiatry De Crespigny Park, Denmark Hill, London SE5 8AF

A study has been made of aneuploidy in the cultured lymphocytes of senile dements (46 females and 8 males), arteriosclerotic dements (10 females and 8 males) and normal geriatric controls (55 females and 18 males). Contrary to previous reports of senile dements having a higher degree of hypodiploidy (chromosome loss) than age-matched controls, there were no significant differences between any of the diagnostic groups. The association between individual subjects' age and hypodiploidy is positive, though not significant, with a high degree of individual variation. The reasons for the discrepancies between this and previous studies are discussed as are possible future lines of research in this field.


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