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© 1983 Oxford University Press

research-article

CYTOGENETIC CHANGES IN PATIENTS WITH SENILE DEMENTIA

I. NORDENSSON, Associate Professor, G. BECKMAN, Professor, R. ADOLFSSON, Assistant Physician-in-Chief, G. BUCHT, Assistant Physician-in-Chief and B. WINBLAD, Professor

Department of Medical Genetics, University of Umeá S-901 87 Umeá, Sweden
Department of Psychiatry, University of Umeá S-901 87 Umeá, Sweden
Department of Geriatric Medicine, University of Umeá S-901 87 Umeá, Sweden

Correspondence to: Gösta Bucht, M.D., Umeá Dementia Research Group, Department of Geriatric Medicine, University of Umeá, S-901 87 Umeá, Sweden.

Chromosome analyses were performed on lymphocytes from patients with Alzheimer type dementia, multi-infact dementia, Down's syndrome and healthy controls. At least 100 cells were scored from each individual. A significant increase in aneuploidy was observed in the demented patients compared to controls but there was no difference between multi-infarct dementia and senile dementia of Alzheimer type. Nor was there any sex difference in the different groups. Also there was a significantly increased frequency of structurally altered chromosomes among the patients with senile dementia of Alzheimer type compared to other forms of dementis. In the control group such an anomaly was not observed.


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