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© 1984 Oxford University Press

research-article

LOW SERUM VITAMIN B12 IN ALZHEIMER-TYPE DEMENTIA

MARTIN G. COLE, Director of Psychogeriatrics1 and JAROSLAV F. PRCHAL, Director of Haematology Services2

1St. Mary's Hospital, Assistant Professor of Psychiatry McGill University Montreal
2St. Mary's Hospital Associate Professor of Medicine McGill University Montreal

Serum vitamin B12 levels (as determined by radio-immunoassay) were measured in 20 subjects aged 65 years and over with Alzheimer-type dementia, 20 age-matched subjects with non-Alzheimer type dementia and 20 age-matched subjects with no dementia. Serum vitamin B12 levels were significantly lower and serum vitamin B12 deficiency was significantly more frequent in subjects with Alzheimer-type dementia and were independent of age, sex, haematological abnormality or serum folate.


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