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© 1984 Oxford University Press

research-article

THE MAIN HISTOCOMPATIBILITY COMPLEX AND AGEING IN MICE AND MEN

KALMAN KAFETZ, Senior Registrar*

Geriatric Medicine Unit, Department of Medicine, Hammersmith Hospital and Royal Postgraduate Medical School London W12OHS

*Present address: Consultant Physician in Geriatric Medicine, Whipps Cross Hospital, London Ell 1NR.

Studies of the relationship between the main histocompatibility complex and survival into old age are reviewed. In mice there is some evidence that the H2 system is involved with longevity. Studies in very old humans may help to explain the survival of genes modulating different immune responsiveness.


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