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© 1984 Oxford University Press

research-article

DRUG INDUCTION OF HEPATIC ENZYMES IN THE ELDERLY

M. W. PEARSON, Senior Registrar and C. J. C. ROBERTS, Consultant and Senior Lecturer in Clinical Pharmacology

Department of Geriatric Medicine, Bristol General Hospital, Bristol Royal Infirmary Bristol BS2 8HW
Department of Medicine, Bristol Royal Infirmary Bristol BS2 8HW

Previous workers have suggested that hepatic enzyme induction by drugs does not occur in the elderly. We have studied the effect of a potent enzyme inducer—glutethimide—on a group of nine patients over the age of 70 years, using antipyrine clearance as a measure of hepatic drug metabolism. After six days treatment with glutethimide, antipyrine clearance rose from 22.8 ± 4.5 ml/min to 38.3 ± 7.6 ml/min (P < 0.001). The results suggest that the elderly are at risk for the full range of drug interactions due to hepatic microsomal enzyme induction.


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