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© 1985 Oxford University Press

research-article

A COMPARISON OF THE ERYTHROCYTE SEDIMENTATION RATE AND SERUM C-REACTIVE PROTEIN CONCENTRATION IN ELDERLY PATIENTS

R. A. KENNY, Registrar1, A. P. SAUNDERS, Senior House Officer1, A. COLL, Senior House Officer1, M. G. HARRINGTON, Research Registrar1, D. CASPI, Research Fellow2, H. M. HODKINSON, Professor of Geriatric Medicine1 and M. B. PEPYS, Reader in Immunological Medicine2,*

1Geriatric Medicine Unit, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital Du Cane Road, London W12 OHS
2MRC Acute Phase Protein Research Group, Immunological Medicine Unit, Royal Postgraduate Medical School, Hammersmith Hospital Du Cane Road, London W12 OHS

*Present appointment: Professor of Immunological Medicine.

Fifty-five consecutive admissions to an acute genatic unit were studied prospectively. Individuals were classified according to the obvious presence or absence of an active disease process on admission and their serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were measured then and five days later. There was no significant difference between the ESR values in the two groups either on admission or at day 5, nor was there any significant change between admission and day 5. In contrast, CRP values were very significantly higher in the active than in the non-active group and there were marked changes over the 5-day period corresponding to changes in clinical condition. These results indicate that the serum CRP concentration is superior to the ESR as an objective, non-specific marker for disease activity in the elderly.

accepted in revised form July 5, 1984.


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