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© 1985 Oxford University Press

research-article

IMMUNOLOGICAL TESTS AND THE DIAGNOSIS OF DEMENTIA IN ELDERLY WOMEN

NIGEL K. G. SMITH, Consultant Physician in Geriatric Medicine and RICHARD J. POWELL, Consultant Immunologist and Senior Lecturer

Department of Health Care of the Elderly, University Hospital Nottingham NG7 2UH
Department of Immunology, University Hospital Nottingham NG7 2UH

Serum immunoglobuhns and circulating antinuclear antibodies were assayed in 91 elderly female in-patients with dementia. Clinical criteria were used to distinguish a group with multi-infarct dementia from those with senile dementia of Alzheimer type and the results were compared with those of 19 age-matched controls. Dementia patients aged 85 and over had a higher prevalence of antinuclear antibodies (P<<0.05) and those aged 90-95 had higher levels of IgA than younger age groups (P<<0.025). IgG levels were higher than controls in the 'multi-infarct' group (P<<0.025).

accepted in revised form August 22, 1984.


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