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© 1985 Oxford University Press

research-article

AUTONOMIC RESPONSES TO GLUCOSE INGESTION IN ELDERLY SUBJECTS WITH ORTHOSTATIC HYPOTENSION

BRIAN J. ROBINSON, Research Student, RALPH H. JOHNSON, Dean and Professor of Medicine, DAVID G. LAMBIE, Research Officer and KAREN T. PALMER, Specialist in Genatrics

Wellington Clinical School of Medicine, Wellington Hospital Wellington New Zealand

The cardiovascular and plasma catecholamine responses to oral glucose (50 g) ingestion were investigated in five elderly subjects with orthostatic hypotension and five elderly control subjects. All the orthostatic hypotension subjects showed blood pressure falls after glucose ingestion, as compared to only one of the control subjects. Significantly greater falls in the orthostatic hypotension as compared to control patients were observed for systolic blood pressure (P<0.01) at 60 and 90 min following glucose and mean blood pressure (P<0.05) at 60 min following glucose. The orthostatic hypotension subjects did not have evidence of reduced heart-rate or plasma catecholamine responses to the glucose ingestion. It is concluded that, in elderly patients with orthostatic hypotension, disorder of blood pressure control may also cause hypotension asssociated with eating.

accepted in revised form October 1, 1984.


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