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© 1986 Oxford University Press

research-article

THE METABOLIC EFFECTS OF THIAZIDE THERAPY IN THE ELDERLY: A POPULATION STUDY

MICHAEL PETRI, Senior Registrar*, PETER CUMBER, Senior House Officer, LINDSEY GRIMES, Research Technician, DAVID TREBY, Chief M.L.S O., RICHARD BRYANT, G.P Trainee, DAVID RAWLINS, General Practitioner and HARMUT ISING, Physicist

Department of Geriatric Medicine, St Martin's Hospital Midford Road, Bath
The Surgery Anchor Road, Coleford, Nr. Bath
Bundesgesundheitsamt Postfach, 33 00 13, D-1000 Berlin 33, FDR

*Present appointment: Consultant Physician, Department of Geriatric Medicine, Poole General Hospital, Poole, Dorset BH15 2JB.

The metabolic consequences of thiazide diuretics are well known. The elderly to whom these agents are widely prescribed may be particularly susceptible. To quantify this metabolic risk, plasma and intracellular electrolytes and plasma glucose were measured in the elderly population of a Somerset village. Highly significant reductions in both plasma and cellular magnesium and potassium were found in the 47 thiazide-treated people. Forty-eight per cent of the thiazide-treated group were hypomag-nesaemic and 28% were hypokalaemic. Thus, magnesium and potassium depletion are commonly associated with thiazide therapy in the elderly. These metabolic effects should be considered carefully prior to the use of these agents.

accepted in revised form November 26, 1985.


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