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© 1986 Oxford University Press

research-article

DOES RADIOLABELLED DIPHOSPHONATE RETENTION REFLECT BONE METABOLISM IN THE ELDERLY?

A. J. WEBB, Senior Registrar in Geriatric Medicine, B. SINHA, Registrar In Geriatric Medicine, R. S. J. BRIGGS, Senior Lecturer in Geriatric Medicine, J. FLEMING, Principal Physicist and D. ACKERY, Consultant in Nuclear Medicine

Department of Nuclear Medicine Southampton SO9 4XY
Southampton General Hospital, Southampton SO9 4XY

The 24-h whole-body retention of diphosphonates (WBR), a useful measure of bone metabolism in young subjects, was measured in 27 elderly subjects (19 from home and eight in-patients). WBR rose with increasing age (r=0.55, P<0.01) and was negatively correlated with renal function (r= –0.60, P<0.01). In five subjects given vitamin D, WBR did not fall. The measurement of WBR in the elderly has to be assessed in the light of an accurate assessment of renal function and so is rarely clinically useful.

accepted in revised form December 12, 1985.


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