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© 1989 Oxford University Press

research-article

Protein Turnover in Malnourished Elderly Subjects: The Effects of Refeeding

D. BEAUMONT, A. B. LEHMANN and O. F. W. JAMES

The University of Newcastle upon Tyne, Department of Medicine (Geriatrics) Floor 4, Clinical Block, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH
Department of Medicine (Geriatrics), Queen Elizabeth Hospital Gateshead NE9 6SX
Department of Health Care of the Elderly, University of Nottingham Medical School, Queen's Medical Centre Nottingham NG7 2UH

Address correspondence to Professor O. F. W. James

A primed constant-rate infusion of L-(l-14C)-leucine was used to assess protein flux, synthesis, and breakdown in a group of malnourished elderly subects (n = 9) and a group of age-matched healthy elderly control subjects (n = 9). No significant differences between the two groups were observed in measures of protein metabolism. Four out of six malnourished subjects, restudied after a period of dietary replenishment, showed non-significant increases in protein synthesis and breakdown. Plasma insulin concentrations were significantly suppressed (p < 0.05) and plasma growth hormone and cortisol concentrations significantly elevated (p < 0.05) in the malnourished subjects before and after refeeding compared with the healthy elderly controls.

Revision received July 7, 1988.
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