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© 1989 Oxford University Press

research-article

Age and the Pharmacokinetics of Morphine

S. P. BAILLIE, D. N. BATEMAN, P. E. COATES and K. W. WOODHOUSE

Geriatric Pharmacology Research Group, Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne NE1 7RU
Napp Laboratories Ltd. Cambridge

Eight healthy young and nine healthy elderly volunteers received 10 mg morphine sulphate as an intravenous infusion, an oral solution and a slow-release tablet (MST Continus, Napp Laboratories) on three separate occasions. Pharmacokinetic profiles of morphine base were measured over a 24-h period using 13 sampling times.

The elderly group showed decreased morphine clearance with a trend to a smaller volume of distribution. They achieved higher maximum plasma concentrations (Cmax) after both oral formulations and had larger areas under the plasma concentration-time curves. The times to reach maximum concentrations were the same in both groups for all formulations.

accepted in revised form September 21, 1988.


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