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© 1990 Oxford University Press

research-article

Cardiac Enzyme Changes in Elderly Fallers

DAVID G. SWAIN1,4, PETER G. NIGHTINGALE3, ROUSSEAU GAMA3 and BRENDAN M. BUCKLEY2,3

1Department of Geriaritic Medicine Sandwell District General Hospital, West Bromwich B71 4HJ
2Department of Biochemistry Sandwell District General Hospital, West Bromwich B71 4HJ
3Wolfson Research Laboratories, Queen Elizabeth Medical Centre Birmingham, B15 2TH

4Address for correspondence: Dr M. C. Ward, Department of Geriatric Medicine, St George's Hospital, Tooting, London SW17 OREAddress for correspondence: Dr M. C. Ward, Department of Geriatric Medicine, St George's Hospital, Tooting, London SW17 ORE

The pattern of enzyme changes in elderly fallers admitted to an acute geriatric unit was investigated.Creatine kinase (CK), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) activities were measured daily for 3 days after admission in all patients in whom a fall preceded admission. Of 270patients, 52 (19%) had fallen prior to admission, of whom five (10%) had an acute myocardial infarction (AMI).In fallers without an AMI in whom a history was available, CK and AST activities were significantly higher (p < 0.05) in patients who had spent more than 1 hour on the floor than in those who had spent less than 1 hour. No other clinical factor affected enzyme activities. CK and AST activities were raised in 66% and 40%, respectively, of fallers without an AMI. Elevation of CK and AST activities in elderly fallers is likely to be a result of the fall itself rather than of an AMI.

Revision received September 29, 1989.
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