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© 1991 Oxford University Press

research-article

The Association of Age with Aspirin Esterase Activity in Human Liver

CATHERINE YELLAND, JOANNA SUMMERBELL, ELIZABETH NICHOLSON, BARBARA HERD, HILARY WYNNE and KENNETH W. WOODHOUSE

Geriatric Clinical Pharmacology Unit, Department of Medicine (Geriatrics) and Wolfson Unit of Clinical Pharmacology, The University Newcastle upon Tyne NE1 7RU

The activity of the phase 1 enzyme aspirin esterase was studied in liver tissue from 16 patients, aged 45–88 years. No correlation between age and enzyme activity was found in post-mitochondrial, cytosolic and microsomal fractions. These results provide further evidence that age is not a major determinant of the activity of hepatic drug-metabolizing enzymes in man.

Received March 1, 1990;
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