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© 1991 Oxford University Press

research-article

Tamoxifen and Partial Oestrogen Agonism in Postmenopausal Women

A. MIODRAG, P. EKELUND, R. BURTON and C. M. CASTLEDEN

Department of Medicine for the Elderly, Leicester General Hospital Gwendolen Road, Leicester LE5 4PW
Present address: P. Ekelund, Department of Geriatrics Vasa Hospital S-411 33 Gothenburg, Sweden Vasa Hospital S-411 33 Gothenburg, Sweden

The effect of tamoxifen on the vaginal mucosa and on serum oestrone, oestradiol and gonadotrophin concentrations was investigated in a group of nine postmenopausal women with non-metastatic breast cancer. Compared with fit age-matched controls, the vaginal pH in the tamoxifen-treated group was significantly lower and was comparable to levels in fertile women. Two thirds of tamoxifen-treated women had well oestrogenized vaginal smears compared with none in the control group. Follicle-stimulating hormone was significantly reduced, whilst oestrone and oestradiol levels remained unchanged. We conclude, therefore, that tamoxifen has oestrogen-agonistic properties particularly evident in postmenopausal women, even though it is primarily an antioestrogenic drug.

Received April 4, 1990;
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