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© 1991 Oxford University Press

research-article

The Effect of Dietary Supplementation with Vitamins A, C and E on Cell-mediated Immune Function in Elderly Long-stay Patients: A Randomized Controlled Trial

N. D. PENN, L. PURKINS, J. KELLEHER, R. V. HEATLEY, B. H. MASCIE-TAYLOR and P. W. BELFIELD

Department of Medicine for the Elderly, St James's University Hospital Beckett Street, Leeds LS9 7TF
Department of Medicine, St James's University Hospital Beckett Street, Leeds LS9 7TF
Department of Medicine for the Elderly, The General Infirmary at Leeds Great George Street, Leeds

Thirty elderly long-stay patients were randomly allocated to receive either placebo or dietary supplementation with vitamins A, C and E for 28 days. Nutritional status and cell-mediated immune function were assessed before and after the period of supplementation.

Following vitamin supplementation, cell-mediated immune function improved as indicated by a significant increase in the absolute number of T cells (p<0.05), T4 subsets (p<0.05), T4 to T8 ratio (p<0.01) and the proliferation of lymphocytes in response to phytohaemagglutinin (p<0.01). In contrast, no significant changes were noted in the immune function of the placebo group.

We conclude that supplementation with the dietary antioxidants vitamins A, C and E can improve aspects of cell-mediated immune function in elderly long-stay patients.

Revision received August 21, 1990.
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