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© 1992 Oxford University Press

research-article

Renal Prostaglandins, Effective Renal Plasma Flow and Glomerular Filtration Rate in Healthy Elderly Subjects

A. ASOKAN, G. J. FANCOURT, S. E. BENNETT and C. M. CASTLEDEN

Department of Medicine for the Elderly, Leicester General Hospital Gwendolen Road, Leicester LE5 4PW

Address correspondence to Dr G. J. Fancourt

This study tests the hypothesis that the age-associated reduction in glomerular filtration rate (GFR) and the presence of glomerulosclerosis renders effective renal plasma flow (ERPF) prostaglandin dependent. Ten healthy elderly volunteers were studied in a single-blind placebo-controlled manner using indomethacin to suppress the renal prostaglandins. There was no significant difference in ERPF or GFR following indomethacin when compared with placebo.

These results suggest that blocking renal prostaglandins does not significantly alter ERPF or GFR in healthy elderly people.

Received May 20, 1991;
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