Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by McLEAN, K. A.
Right arrow Articles by MORRIS, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McLEAN, K. A.
Right arrow Articles by MORRIS, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 Oxford University Press

research-article

Influence of Age on Plasma Osmolality: A Community Study

K. A. McLEAN, P. A. O'NEILL*, I. DAVIES and J. MORRIS

Department of Geriatric Medicine, University Hospital of South Manchester Nell Lane, Manchester M20 8LR
Department of Medical Statistics, University Hospital of South Manchester Nell Lane, Manchester M20 8LR

*Address correspondence to Dr P. A. O'Neill

We have shown an age-associated increase in plasma osmolality (p <0.001) in 152 randomly selected subjects, living in the community. In the old [mean age 78.0 (7.5) years] the plasma osmolality was 302.2 (300.6–303.8) mOsmol/kg compared with 291.2 (290.0–292.3) mOsmol/kg in the young [39.2 (11.2) years] (p <0.0001). In a further group of 20 screened, health status defined, elderly subjects the plasma osmolality was 298.1 (295.9–300.3) mOsmol/kg, which was significantly higher than the young group (p< 0.0001) but lower than the unscreened old subjects (p=0.005). The variance was also significantly lower (p=0.03).

The results may reflect a loosening of homoeostatic control and highlight the need for care in subject selection in studies of ageing.

Received June 11, 1991;
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
W. H. Loomis, S. Namiki, R. S. Ostrom, P. A. Insel, and W. G. Junger
Hypertonic Stress Increases T Cell Interleukin-2 Expression through a Mechanism That Involves ATP Release, P2 Receptor, and p38 MAPK Activation
J. Biol. Chem., February 7, 2003; 278(7): 4590 - 4596.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. Orlic, W. H. Loomis, A. Shreve, S. Namiki, and W. G. Junger
Hypertonicity increases cAMP in PMN and blocks oxidative burst by PKA-dependent and -independent mechanisms
Am J Physiol Cell Physiol, June 1, 2002; 282(6): C1261 - C1269.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.