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© 1992 Oxford University Press

research-article

Association of Age with Regional Cerebral Oxygen Utilization: A Positron Emission Tomography Study

ALISTAIR BURNS and PIPPA TYRRELL

MRC Cyclotron Unit, Hammersmith Hospital Ducane Road, London W12 0HS

Address for correspondence: Professor A. Burns, Department of Psychiatry, Withington Hospital, West Didsbury, Manchester M20 8LR

Positron emission tomography scans were performed on 14 normal subjects over the age of 50. Cerebral metabolic rate for oxygen (CMRO2) was assessed in a number of cortical and subcortical regions. There was a trend for a decrease in CMRO2 with age but this was significant only in the parietal lobe. There was a suggestion that the age/CMRO2 correlation became less strong with advancing age. CMRO2 in the occipital lobe, subcortical regions and cerebellum was not related to age. The relationship between CMRO2 and age is discussed.

Received March 5, 1992;
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