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© 1992 Oxford University Press

research-article

Assessment of the Clinical Value of Urinary Trypsin Inhibitory Activity in Elderly People

MYRIAM MERLE*, CLAUDE JEANDEL, FRANÇOISE BELLEVILLE-NABET, FRANÇOISE BERTRAND, FRANCIS PENIN, GÉRARD CUNY and JEAN-BERNARD DUREUX

Department of Infectious Diseases CHU Nancy
Department of Internal Medicine CHU Nancy
Biochemistry Laboratory CHU Nancy

* Address for correspondence: Dr M. Merle, Service Pr J. B. Dureux, CHU Brabois, rue du Morvan, 54511—Vandoeuvre Cedex, France

To assess the clinical value of urinary trypsin inhibitory activity (UTIA) in elderly people, a prospective study was carried out over 4 months in our internal medicine department. Two hundred and forty-three patients of more than 60 years of age were included. A positive correlation was observed between UTIA and serum creatinine (p < 10–3).

In the population with serum creatinine of less than 133 µmol/l (200 patients), UTIA was independent of age, sex and serum creatinine. UTIA was compared with seven serum inflammatory proteins titrated on patient admission. The principal interest of UTIA determination appeared in bacterial infections. UTIA was significantly increased in this group (p < 10–4). However, a positive correlation was proved only with C-reactive protein (CRP) (p=9 x 10–4). Nevertheless, CRP appeared to be the best marker of bacterial infectious diseases after receiver operating characteristic curves analysis.

Received April 1, 1992;
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