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© 1993 Oxford University Press

research-article

Relationships between Parathyroid Hormone, 25-Hydroxyvitamin D, and Bone Mineral Density in Elderly Men

SEAN MURPHY*, KAY-TEE KHAW, ANN PRENTICE and JULIET E. COMPSTON

Clinical Gerontology Unit F and G Block, Level 2
Department of Medicine, Level 5 Addenbrooke's Hospital Cambridge CB2 2QQ
MRC Dunn Nutritional Laboratory Downhams Lane, Milton Road, Cambridge CB4 1XJ

*Address correspondence to: Department of Clinical Geratology, Radcliffe Infirmary, Oxford OX2 6HE

This study aimed to determine the relationships between parathyroid hormone, vitamin D status and bone mineral density (BMD) in healthy older men. Subjects [n = 133, mean age (SD) 69.5 (3.1), range 65–76 years] were recruited from two general practices in Cambridge. Blood samples were drawn for measurement of intact parathyroid hormone (1–84, hPTH) and total 25-hydroxyvitamin D. Bone mineral density at the hip and spine was measured by dual-energy X-ray absorptiometry (DEXA).

After adjusting for age and body mass index (BMI), PTH was negatively correlated with trochanteric (r= –0.24, p = 0.007), intertrochanteric (r=– 0.29, p=0.001), and Ward's Triangle BMD (r = –0.15, p = 0.087). By analysis of variance, controlling for age and BMI, PTH showed a relatively consistent downward trend with increasing tertiles of bone mineral density, especially at the hip.

These results suggest a role of parathyroid hormone in determining hip bone mineral density in a community-based sample of healthy elderly men.

Received August 7, 1992;
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