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© 1993 Oxford University Press

research-article

Repeatability and Relationship between Arterialized Catecholamines and Blood Pressure in Elderly Subjects

J. F. POTTER, M. D. FOTHERBY and I. A. MACDONALD

University Department of Medicine for the Elderly, Leicester General Hospital Leicester LE5 4PW
Department of Physiology and Pharmacology, Queen's Medical Centre Nottingham NG7 2UH

Little work has been conducted to assess repeatability and relation of arterialized plasma catecholamines to blood pressure in elderly subjects. We studied 19 untreated elderly patients with essential hypertension and 19 matched normotensives on two occasions one week apart. After prolonged supine rest, BP, pulse rate and arterialized plasma catecholamine levels were measured. Systolic (SBP) and diastolic (DBP) blood pressure, plasma adrenaline (A) and noradrenaline (NA) repeatabilities were similar for the hypertensive and normotensive groups. Mean supine pulse rate was significantly higher in the hypertensive group as were arterialized plasma A, but not NA, levels. For the whole group there was a significant univariate correlation between log plasma A and SBP (r=0.53), DBP (r = 0.59) and pulse rate (r = 0.41). In keeping with previously published work in younger subjects these results indicate a possible role for adrenaline in the maintenance of raised blood pressure levels in elderly people.

Received January 19, 1993;
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