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© 1993 Oxford University Press

research-article

Toxic Epidermal Necrolysis (Lyell Syndrome) in 77 Elderly Patients

SYLVIE BASTUJI-GARIN, MINA ZAHEDI, JEAN-CLAUDE GUILLAUME and JEAN-CLAUDE ROUJEAU

Département de Dermatologie, Hôpital Henri-Mondor, Université Paris XII France

Address correspondence to Dr S. Bastuji-Garin, Département d’Epidémiologie, Faculté de Médecine, Université Paris XII, 8 rue du Général-Sarrail, 94010 Créteil Cedex, France

Toxic epidermal necrolysis is a rare, severe drug-induced disorder characterized by extensive epidermal loss. This study used the data of a national survey looking for all cases which occurred during a five-year period.

The incidence of toxic epidermal necrolysis (cases/million/year) was 2.7 times higher among elderly than among younger adults. In the elderly population no female preponderance was found but clinical patterns were similar. The fatality of toxic epidermal necrolysis was twice as high in the elderly patients (51%) as in the younger (25%). The drugs incriminated in most cases of toxic epidermal necrolysis were the same in both groups (NSAIDs, antibacterials and anticonvulsants).

Received February 16, 1993;
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