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© 1993 Oxford University Press

Neuroendocrine Regulation

Thymus—Pituitary Interactions During Ageing

Rodolfo G. Goya, Maria G. Castro, Peter W. Saphier, Yolanda E. Sosa and Philip J. Lowry

Department of Biochemistry and Physiology, University of Reading Reading
Present address Laboratory of Cellular and Molecular Neurobiology, Department of Physiology, University of Wales College of Cardiff PO Box 902, Cardiff CF1 1SS
Neuroendocrine Gerontology Laboratory, Department of Neurosciences, IMBICE La Plata, Argentina

Address correspondence to: Dr R. G. Goya, IMBICE, 526 (10 y 11), CC# 403, 1900 La Plata, Argentina

We had previously shown that homoeostatic thymus hormone (HTH), an H2A–H2B histone dimer, possesses an age-dependent adrenostirnulatory activity in vivo. It was therefore of interest to investigate the adrenocorticotropin (ACTH)-releasing activity of histones and other related preparations on perifused pituitary cells from young (2–4 months) and mature (16–18 months) rats. Histones and protamines gave a positive interference with the immunoradiometric assays (IRMA) for ACTH and corticotropin releasing hormone (CRH) whereas the histone fragment MB35, as well as nucleohistone and nucleoprotamine complexes did not. The latter three substances induced a significant ACTH response in pituitary cells from young and, to a lesser extent, mature rats. Our results suggest that nucleoprotein complexes released into the extracellular milieu may act as hypophysiotropic signals. On the other hand, the responsiveness of pituitary cells to these signals seems to decrease with the age of the donor.


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