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© 1993 Oxford University Press

Genetic Mechanisms

Studies on DNA Repair Defects in Degenerative Brain Disease

Michael E. T. I. Boerrigter and Jan Vijg

Division on Aging, Harvard Medical School, and Beth Israel Hospital, Division of Gerontology 330 Brookline Avenue, Boston, MA 02215 USA
Ingeny B.V. PO Box 685, 2300 AR Leiden, The Netherlands

Using the alkaline filter elution technique we determined the induction and disappearance of single-strand breaks (SSB) in freshly isolated peripheral blood lymphocytes (PBL) from 43 Alzheimer disease (AD) patients and from 48 healthy, age- and sex-matched control subjects following in vitro exposure to N-ethyl-N-nitrosourea (ENU), methyl methanesulphonate (MMS), or gamma ({gamma})-radiation. No differences in SSB disappearance between AD patients and controls were observed after treatment of PBL with MMS or {gamma}-rays. After treatment with ENU, however, the amount of SSB disappearance was significantly lower in PBL from familial, but not in PBL from sporadic AD patients. ENU repair in PBL from neurological controls was comparable to that found in normal age-matched controls, indicating that the lower amount of ENU repair in familial AD patients is not a consequence of neuronal degeneration. These tentative findings are discussed in relation to the aetiology of AD.


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