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© 1994 Oxford University Press

research-article

Hypopituitarism: A Difficult Diagnosis in Elderly People but worth a Search

SARUP C. TAYAL, SUSHIL K. BANSAL and DINESH K. CHADHA

Department of Geriatric Medicine, Sunderland District General Hospital Kayall Road, Sunderland SR2 7TP
Present address: Department of Medicine for the Elderly, Tickhill Road Hospital Balby, Doncaster DN4 8QL

Address correspondence to Dr S. C. Tayal, 21 Angram Drive, Grange Town, Sunderland SR2 7RD

Hypopituitarisni is uncommon in elderly people. We report 12 cases of hypopituitarism diagnosed after the age of 60 (range 63–89, mean 74.9) years over a 10-year period. Aetiology was evident in eight cases, viz, pituitary tumour in six and previous post-partum haemorrhage and giant aneurysm of carotid artery in one each. The presentation was often non-specific with symptoms such as lethargy, pallor, falls, urinary incontinence, confusion, fever and flexion contractures. Subtle clues to the condition were missed in four cases resulting in delayed diagnosis. Although levels of pituitary trophic hormones are generally low in this condition, the thyrotrophin (TSH) was normal in seven cases in the present series. Normal levels of serum sodium and potassium did not exclude cortisol deficiency. Hormone replacement therapy resulted in improved quality of life. Physicians dealing with elderly patients should bear this easily treated condition in mind.

Received December 30, 1993;
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