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© 1994 Oxford University Press

research-article

Familial Alzheimer's Disease and Vitamin B12 Deficiency

A McCADDON, C. L. KELLY and GÖSTA TIBBLIN

Gardden Road Surgery, Rhosllanerchrugog Wrexham LL14 2EN, Clwyd, North Wales
Rotherham General Hospital Moorgate Road, Rotherham S60 2UD, S. Yorkshire

A kindred with autosomal dominant familial Alzheimer's disease in which a mutation results in a valine to glycine substitution at amyloid precursor protein codon 717 has recently been described. Individuals in this pedigree were studied retrospectively and prospectively, to evaluate the relationship, if any, between Alzheimer's disease and vitamin B deficiency. The presence of Alzheimer's disease was found to be associated with lower serum vitamin B values compared with unaffected family members. There were no significant differences between macrocytosis, the presence of anaemia, serum folate or red cell folate between affected and unaffected family members. The implications of this finding are discussed with regard to previous descriptions of an association, and in relation to the clinical features of this particular kindred.

Received February 7, 1994;
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