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© 1994 Oxford University Press

research-article

Age, Smoking and the Activity of the Mono-oxygenase Hydroxylase in Iso Mydrocarbon Human Periphera

GRAEME GEORGE, SINEAD O'MAHONY and KEN WOODHOUSE

University Department of Geriatric Medicine, Cardiff Royal Infirmary (West Wing) Newport Road, Cardiff CF2 1SZ

Address correspondence to Professor K. Woodhouse

Age-associated changes in the microsomal mono-oxygenase enzyme, aryl hydrocarbon hydroxylase (AHH), were investigated in peripheral blood monocytes isolated from young and elderly subjects. Young subjects were selected from the age group < 35 years; elderly subjects were > 70 years. AHH activity, expressed as nM 3-hydroxy benzopyrene formed/106 cells/h of incubation, was similar in young and elderly non-smokers (elderly = 6.7 ± 1.8; young = 9.1 ± 0.9; p > 0.05). In smokers, contrary to some previous reports, AHH activity was not significantly higher than in non-smokers of similar age (elderly smokers = 8.6± 1.0; young smokers = 10.5 ± 2.4; p > 0.05). There was no significant difference between young and elderly smokers (p > 0.05).

We conclude that: (a) AHH activity is similar in young and old non-smoking individuals; (b) no significant differences were detected in in vivo induction of this enzyme activity between smokers and non-smokers.

Revision received February 28, 1994.
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