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© 1995 Oxford University Press

research-article

Age-associated Alterations in Thirst and Arginine Vasopressin in Response to a Water or Sodium Load

IOAN DAVIES*, PAUL A. O'NEILL, KATHLEEN A. MCLEAN, JAMES CATANIA and DEREK BENNETT

University of Manchester, Department of Geriatric Medicine, University Research and Teaching Building, Withington Hospital Nell Lane, Manchester, M20 8LR
Department of Geriatric Medicine, Withington Hospital Nell Lane, Manchester, M20 8LR
Department of Medical Statistics, Withington Hospital Nell Lane, Manchester, M20 8LR

*Address correspondence to Dr I. Davies, University of Manchester, School of Biological Sciences, 1.124 Stopford Building, Oxford Road, Manchester, M13 9PT

We have examined simultaneous changes in thirst, plasma osmolality and arginine vasopressin, after oral water loading or hypertonic saline infusion. The studies were carried out in the same subjects, comprising young controls aged 26.8 years (SD 4.8, n= 10) and health status-defined elderly people aged 72.1 years (SD 3.1, n= 10). Water loading caused significant falls in plasma osmolality (p < 0.001) and thirst (p < 0.001), but there was no variation with age. Infusion with 462 mmol/1 of sodium chloride increased plasma osmolality significantly (p < 0.001), but there was no variation with age (p = 0.12). The perception of thirst during the osmotic loading experiment was recorded differently by the two age groups (p < 0.0001). However, linear regression analysis showed no age difference in the relationship between thirst and plasma osmolality during osmotic loading. During osmotic loading the relationship between the plasma concentration of arginine vasopressin in response to increasing plasma osmolality varied significantly (slope: p = 0.02; intercept: p = 0.02). Plasma arginine vasopressin rose more rapidly with increasing plasma osmolality in old subjects.

Revision received July 17, 1994.
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