Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by AMAR, K.
Right arrow Articles by BUCKS, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by AMAR, K.
Right arrow Articles by BUCKS, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1995 Oxford University Press

research-article

The Relationship between White Matter Low Attenuation on Brain CT and Vascular Risk Factors: A Memory Clinic Study

KHALED AMAR, TIM LEWIS, GORDON WILCOCK, MARGARET SCOTT and ROMOLA BUCKS

Frenchay Hospital, University of Bristol Bristol BS16 1LE
Blackberry Hill Hospital Bristol

In order to discover the prevalence of white matter low attenuation (WMLA) in the brain and its relationship to vascular risk factors in our Memory Disorders Clinic patients we assessed brain CT scans of 202 patients referred to our clinic between January 1991 and December 1992.

One hundred patients (49.5%) had WMLA, and the prevalence increased with increasing severity of cognitive impairment. It was 12% in patients with no evidence of dementia, 32% in those with isolated memory loss, and 59% in patients with possible or probable dementia.

There was a correlation between WMLA and systolic blood pressure, heart disease, peripheral vascular disease, focal neurological signs on examination and central atrophy on CT. No correlation was found between WMLA and low blood pressure, blood glucose or cholesterol level. Our findings indicate that WMLA probably plays an important role in cognitive impairment, and that thromboembolic rather than haemodynamic factors are probably more important in its pathogenesis.

Revision received January 19, 1995.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Psychosom. Med.Home page
S. R. Waldstein, C. F. Tankard, K. J. Maier, J. R. Pelletier, J. Snow, A. W. Gardner, R. Macko, and L. I. Katzel
Peripheral Arterial Disease and Cognitive Function
Psychosom Med, September 1, 2003; 65(5): 757 - 763.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
M. C. Morris, P. A. Scherr, L. E. Hebert, R. J. Glynn, D. A. Bennett, and D. A. Evans
Association of Incident Alzheimer Disease and Blood Pressure Measured From 13 Years Before to 2 Years After Diagnosis in a Large Community Study
Arch Neurol, October 1, 2001; 58(10): 1640 - 1646.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
K. Amar and G. Wilcock
Fortnightly Review: Vascular dementia
BMJ, January 27, 1996; 312(7025): 227 - 231.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.