© 1996 Oxford University Press
research-article |
Is Depression in Elderly People followed by Dementia? A Retrospective Cohort Study based in General Practice
Department of General Practice, University of Limburg PO Box 616, 6200 MD Maastricht, The Netherlands
Department of Methodology and Statistics, University of Limburg PO Box 616, 6200 MD Maastricht, The Netherlands
MEMIC, University of Limburg PO Box 616, 6200 MD Maastricht, The Netherlands
We used a retrospective cohort study design to test the hypothesis of a relation between old-age depression and subsequent dementia. The study sample comprised 19 103 patients aged 50 or more and born after 1910, included in a family-practice-based registration network. We estimated odds ratio (OR) and 95% confidence interval (95% CI) for a diagnosis of dementia in patients with or without previous late-onset depression and survival analysis, including hazard ratios resulting from Cox regression analysis.
The OR for a diagnosis of dementia subsequent or not to late-onset depressions was 2.38 (95% CI 1.08–5.06). No significant difference between patients with or without old-age depression was found at survival analysis: p = 0.26 (log rank test). Hazard ratio for patients with and without previous old age depression was 2.55 (95% CI 1.19–5.47). We conclude that there is a significant relation between old-age depression and subsequent dementia in patients aged 50 or more and born after 1910. This supports the hypothesis of old-age depression being a predictor, and possibly a causal factor, of subsequent dementia.
Revision received October 20, 1995.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. L. Ownby, E. Crocco, A. Acevedo, V. John, and D. Loewenstein Depression and Risk for Alzheimer Disease: Systematic Review, Meta-analysis, and Metaregression Analysis. Arch Gen Psychiatry, May 1, 2006; 63(5): 530 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Barnes, G. S. Alexopoulos, O. L. Lopez, J. D. Williamson, and K. Yaffe Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the cardiovascular health study. Arch Gen Psychiatry, March 1, 2006; 63(3): 273 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. G. Leentjens Depression in Parkinson's Disease: Conceptual Issues and Clinical Challenges J Geriatr Psychiatry Neurol, September 1, 2004; 17(3): 120 - 126. [Abstract] [PDF]
|
|
|
|
 |
|
 C. G. Lyketsos and H. Lee Commentary: Insulin Resistance as a Link Between Affective Disorder and Alzheimer's Disease: A Hypothesis in Need of Further Refinement J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2004; 59(2): M185 - 187. [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Green, L. A. Cupples, A. Kurz, S. Auerbach, R. Go, D. Sadovnick, R. Duara, W. A. Kukull, H. Chui, T. Edeki, et al. Depression as a Risk Factor for Alzheimer Disease: The MIRAGE Study Arch Neurol, May 1, 2003; 60(5): 753 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. T. J. L. Ensinck, A. G. Schuurman, M. van den Akker, J. F. M. Metsemakers, A. D. M. Kester, J. A. Knottnerus, and F. Buntinx Is There an Increased Risk of Dying after Depression? Am. J. Epidemiol., December 1, 2002; 156(11): 1043 - 1048. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Schuurman, M. van den Akker, K. T.J.L. Ensinck, J. F.M. Metsemakers, J. A. Knottnerus, A. F.G. Leentjens, and F. Buntinx Increased risk of Parkinson's disease after depression: A retrospective cohort study Neurology, May 28, 2002; 58(10): 1501 - 1504. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Zsembik and M. K. Peek Race Differences in Cognitive Functioning Among Older Adults J. Gerontol. B. Psychol. Sci. Soc. Sci., September 1, 2001; 56(5): S266 - 274. [Abstract] [Full Text]
|
|
|
|
|
|
E. E. Femia, S. H. Zarit, and B. Johansson The Disablement Process in Very Late Life: A Study of the Oldest-Old in Sweden J. Gerontol. B. Psychol. Sci. Soc. Sci., January 1, 2001; 56(1): 12P - 23. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. A. Lockwood, G. S. Alexopoulos, T. Kakuma, and W. G. Van Gorp Subtypes of Cognitive Impairment in Depressed Older Adults Am J Geriatr Psychiatry, August 1, 2000; 8(3): 201 - 208. [Abstract] [Full Text]
|
|
|
|
|
|
P. Chen, M. Ganguli, B. H. Mulsant, and S. T. DeKosky The Temporal Relationship Between Depressive Symptoms and Dementia: A Community-Based Prospective Study Arch Gen Psychiatry, March 1, 1999; 56(3): 261 - 266. [Abstract] [Full Text] [PDF]
|
|