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© 1996 Oxford University Press

research-article

Unexplained Macrocytosis in Elderly Patients

M. Y. MAHMOUD1, M. LUGON*,2 and C. C. ANDERSON1

1Department of Haematology
2Department of Elderly Medicine, Whipps Cross Hospital Whipps Cross Road, Leytonstone, London ElI 1NR

*Address correspondence to Dr M. Lugon

One hundred and twenty-four patients over the age of 75 years were assessed for the cause of their macrocytosis (MCV > 95 fl). A definitive diagnosis was reached in 75/124 (60%) by non-invasive techniques. The remainder underwent a bone marrow biopsy yielding a definitive diagnosis in a further six patients who had an identifiable myelodysplastic syndrome (MDS). A high proportion of the remainder had morphological abnormalities which fitted with no recognized pathological entity. It is suggested that these may represent MDS in evolution.

Revision received February 5, 1996.
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