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© 1996 Oxford University Press

research-article

Age-related Changes in 0-Deethylase and Aidrin Epoxidase Activity in Mouse Skin and Liver Microsomes

DELYTH WILLIAMS and KEN WOODHOUSE

Department of Geriatric Medicine, University of Wales College of Medicine 3rd Floor, Academic Centre Llandough Hospital, Penarth, South Glamorgan CF64 2XX

The metabolism of three model substrates for the cytochrome P450 dependent mono-oxygenase enzyme system (P450-MMO) was studied in microsomes isolated from skin and liver of young adult and senescent C57B1/6J mice. The substrates chosen were aldrin (AE), 7-ethoxycoumarin (EOC), and 7-ethoxyresorufin (EOR).

Both EOC and EOR activities were lower in senescent skin. By contrast, no-age related changes were seen in senescent liver. AE was similar in young and old, in both tissues.

We suggest that some important age-related differences in cutaneous xenobiotic metabolism do occur, but that these are not mirrored by hepatic differences, and are substrate specific. Previous work from these laboratories would also suggest significant species differences.

Keywords: Cytochrome P450, Drug metabolism, Ageing

Received March 18, 1996;
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