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© 1998 Oxford University Press

other

Prolonged digitoxin half-life in very elderly patients

THOMAS BØHMER and ARNE RØSETH

Department of Medicine, Aker University Hospital 0514 Oslo, Norway

T Bohmer Fax: (+47) 22 89 4008

The digitoxin half-life in elderly patients in the eight and ninth decade was more prolonged (mean ± SD: 25 ± 9 days) than in younger people (6.7 ± 1.7). These elderly patients accumulated digitoxin even on a dose of 0.05 mg/ day. The symptoms of digitoxin intoxication disappeared on discontinuation of medication. When digitoxin is used in the treatment for heart failure in the very elderly patients, one should be aware of the possibility of digitoxin intoxication, even on a low dose.

Keywords: digitoxin, digitoxin-bis digitoxoside, drug toxicity, elderly, heart failure

Received May 14, 1996;
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