Age and Ageing, Vol 28, 205-209, Copyright © 1999 by British Geriatrics Society
MA Rogers and DG Simon
BACKGROUND: epidemiological studies of Alzheimer's disease and aluminium
intake have focused on aluminium in drinking water. There have been no
studies investigating the relation between the disease and the consumption
of foods containing large amounts of aluminium additives. OBJECTIVES: to
conduct a pilot study to determine whether dietary intake of aluminium
additives differs in individuals with and without Alzheimer's disease.
DESIGN: matched case-control study. Controls were matched to cases on age,
gender and date of admission to the centre. SETTING: Syracuse, New York,
USA. SUBJECTS: 46 participants comprising 23 matched sets. METHODS:
residents of the Loretto Geriatric Center with and without newly-diagnosed
Alzheimer's disease were selected. Next-of-kin were asked to complete
information on the resident's medical history, lifestyle behaviour and
dietary intake before admission to the centre. An expanded form of the
Health Habits and History Questionnaire was used to determine dietary
intake. Consumption of foods containing elevated levels of aluminium
additives was compared between cases and controls. RESULTS: the crude odds
ratio for daily intake of foods containing high levels of aluminium was 2.0
and, when adjusted for covariates, was 8.6 (P=0.19). Intake of pancakes,
waffles, biscuits, muffins, cornbread and/or corn tortillas differed
significantly (P=0.025) between cases and controls. Adjusted odds ratios
were also elevated for grain product desserts, American cheese, chocolate
pudding or beverages, salt and chewing gum. However, the odds ratio was not
elevated for tea consumption. CONCLUSION: past consumption of foods
containing large amounts of aluminium additives differed between people
with Alzheimer's disease and controls, suggesting that dietary intake of
aluminium may affect the risk of developing this disease. Larger studies
are warranted to corroborate or refute these preliminary findings.
ARTICLES
A preliminary study of dietary aluminium intake and risk of Alzheimer's disease
Department of Medicine, State University of New York Health Science Center, Syracuse 13210, USA. rogersm@vax.cs.hscsyr.edu
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