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Age and Ageing, Vol 28, 217-220, Copyright © 1999 by British Geriatrics Society

ARTICLES

Relationships between age, dehydro-epiandrosterone sulphate and plasma glucose in healthy men

N Thomas, HA Morris, F Scopacasa, JM Wishart and AG Need
Division of Clinical Biochemistry, Institute of Medical and Veterinary Science, Adelaide, SA, Australia.

BACKGROUND: dehydro-epiandrosterone sulphate (DHEAS) has been reported to ameliorate diabetes mellitus in rats. AIM: we investigated the relationships between plasma glucose, age, serum DHEAS and weight in healthy men. METHODS: we measured the serum DHEAS, fasting plasma glucose, plasma cortisol and body mass index in 169 subjects (mean age 46.5 years). RESULTS: there was a significant decline in serum DHEAS with age (P < 0.0001). Multiple linear regression showed significant relationships with plasma glucose for all measured variables. Age was not a significant determinant of plasma glucose after adjusting for log serum DHEAS, body mass index and log serum cortisol. CONCLUSIONS: a lowered serum DHEAS is paralleled by an elevated plasma glucose within the normal reference interval, and this may contribute to the rise in fasting plasma glucose which occurs with ageing.
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