Age and Ageing, Vol 28, 341-346, Copyright © 1999 by British Geriatrics Society
P Hobson, A Holden and J Meara
OBJECTIVES: To assess the validity of the Parkinson's Disease Quality of
Life (PDQL) questionnaire, a patient-specific multi-dimensional quality of
life measure, in a community-based sample of patients with Parkinson's
disease (PI)) using standardized measures of disease severity, depressive
symptomatology and cognitive function. DESIGN: A group of 194 patients with
probable PD were randomly selected from a community-based register and were
invited to self-complete the 37-item PDQL. Disease severity was measured by
the disease-specific Webster scale, cognition by the CAMCOG
neuropsychological test and depressive symptomatology by the self-report
15-item GDS-15 geriatric depression scale. RESULTS: A total of 136 patients
returned completed PDQL questionnaires. Significant differences (P <
0.05) emerged between the pooled PDQL score of patients grouped on the
basis of disease severity. Depressive symptoms and cognition were also
associated with poorer perceived quality of life as measured by the PDQL.
CONCLUSIONS: The results of this study are indicative of the validity of
the PDQL as an important additional measurement which reflects the impact
of PD from the patient perspective. It shows poorer quality of life to be
associated with increasing age, disease severity more severe depressive
symptomatology and impaired cognitive functioning. However, the
responsiveness of this instrument in the evaluation of care in PD remains
to be determined.
ARTICLES
Measuring the impact of Parkinson's disease with the Parkinson's Disease Quality of Life questionnaire
University Department of Geriatric Medicine, Glan Clwyd Hospital, North Wales, UK. peterhobson@Hotmail.com
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