Age and Ageing, Vol 28, 385-391, Copyright © 1999 by British Geriatrics Society
K Ritchie, C Gilham, B Ledesert, J Touchon and PO Kotzki
BACKGROUND: Depressive illness in dementia is often assumed to be a unitary
clinical phenomenon. AIM: To describe changes in patterns of depressive
symptomatology with time, and associated changes in cerebral blood flow to
the frontal and temporal regions. METHOD AND RESULTS: 397 elderly people
with sub-clinical cognitive dysfunction were observed over 3 years. Sixteen
percent of them developed dementia during the study The prevalence of
depressive symptomatology was higher in this group than in the general
population, especially in women, who also had higher recovery rates. A
changing profile of depressive symptoms was found in depressed elderly
people progressing to dementia, with fewer affective symptoms and increases
in agitation and motor slowing. These changes were paralleled by greater
reductions in left temporal regional cerebral blood flow than in
non-depressed subjects with Alzheimer's disease. CONCLUSION: In dementia,
there may be two separate and interacting depressive syndromes whose
differentiation may be clinically important.
ARTICLES
Depressive illness, depressive symptomatology and regional cerebral blood flow in elderly people with sub-clinical cognitive impairment
Institut National de la Sante et de la Recherche Medicale, CJF 97-2 Epidemiology of Neurodegenerative Pathologies of the CNS, Montpellier, France.
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