Age and Ageing, Vol 29, 35-39, Copyright © 2000 by British Geriatrics Society
CK Mannesse, FH Derkx, MA de Ridder, AJ Man in 't Veld and TJ van der Cammen
OBJECTIVE: To describe the severity of adverse drug reactions as a factor
in hospital admission of older patients, and to identify risk indicators
for severe adverse drug reactions in these patients. DESIGN: Observational
cross-sectional study. SETTING: Five wards in a university hospital in The
Netherlands. SUBJECTS: Patients aged 70 and over admitted to general
medical wards. METHODS: Use of statistical comparison and Kramer's
algorithm. RESULTS: A severe adverse drug reaction was present in 25 (24%)
of 106 patients. Thirteen patients (12%; 95% confidence interval 6.1-18.6%)
were admitted probably because of an adverse drug reaction. Risk indicators
for a severe adverse drug reaction were a fall before admission (odds ratio
51.3, P = 0.006), gastrointestinal bleeding or haematuria (odds ratio 19.8,
P < 0.001) and the use of three or more drugs (odds ratio 9.8, P =
0.04). CONCLUSION: Adverse drug reactions are an important cause of
hospital admissions in older people. A fall before admission may indicate a
severe adverse drug reaction.
ARTICLES
Contribution of adverse drug reactions to hospital admission of older patients
Department of Geriatric Medicine, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands. c.mannesse@worldonline.nl
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