Age and Ageing, Vol 29, 41-45, Copyright © 2000 by British Geriatrics Society
JE Harrison, S Preston and SB Blunt
BACKGROUND: The 39-item Parkinson's disease questionnaire (PDQ-39) is more
sensitive to functional change than other measures of health and
disability. AIM: To determine the ability of this scale to change over time
and the concurrent validity of some of its subscales. METHODS: We assessed
a cohort of 67 Parkinson's patients for 18 months, using the PDQ-39, the
GHQ-28 general health questionnaire and the Office of Population and Census
Surveys disability instrument. RESULTS: The Office of Population and Census
Surveys disability instrument and GHQ- 28 recorded no significant change,
but the PDQ-39 showed marked changes in levels of functioning. We also
analysed changes on the PDQ-39 subscales as well as concurrent validity
data for several subscales. This showed concurrent validity with the Beck
depression and anxiety inventories, the Barthel index and the Royal
Postgraduate Medical School severity scale. There was a high level of
concurrent validity for all comparisons except for the Barthel index.
CONCLUSION: The PDQ- 39 is a sensitive tool for monitoring change in
patients with Parkinson's disease. It has high levels of concurrent
validity with established measures of mood and motor function.
ARTICLES
Measuring symptom change in patients with Parkinson's disease
CeNeS Ltd, Histon, Cambridge, UK. john.harrison@cenes.co.uk
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