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Age and Ageing, Vol 29, 215-220, Copyright © 2000 by British Geriatrics Society

ARTICLES

IgE-mediated and age-related bronchial hyperresponsiveness in patients with asthma. Relationship to family history of the disease

F Mitsunobu, T Mifune, Y Hosaki, K Ashida, H Tsugeno, M Okamoto, S Harada and Y Tanizaki
Department of Medicine, Misasa Medical Branch, Okayama University Medical School, 827 Yamada, Misasa, Tottori 682-0192, Japan; Corresponding author; Fax: (+81) 858 43 1305; E-mail: fumin@ccews2.cc.okayama-u.ac.jp

Objective. To uncover any differences in the age-related and IgE-mediated pathophysiology of the airways in asthmatics.Method. We examined the relationship of both IgE-mediated bronchial hyperresponsiveness and the cell content of bronchoalveolar lavage fluid with a family history of asthma in 263 patients with asthma classified according to age at onset.Results. Bronchial hyperresponsiveness decreased significantly as age at onset increased in those without a family history. Responsiveness was significantly higher in patients who were 60 years of age at onset who had a family history than in those who did not (P<0.05). The proportion of lymphocytes in bronchoalveolar lavage fluid was significantly higher in patients between 50 and 59 years old at onset who had a family history than those who did not (P<0.05). These results suggest that bronchial hyperresponsiveness and the proportion of bronchoalveolar lavage lymphocytes differ according to the presence of absence of a family history, a finding which is closely related to IgE-mediated allergy in elderly patients at onset.Keywords: asthma, bronchial responsiveness, bronchoalveolar lavage, family history
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