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© 1974 Oxford University Press

research-article

THE EFFECT OF FRUSEMIDE AND ETHACRYNIC ACID ON CARBOHYDRATE METABOLISM

N. K. CONI*, P. W. N. GORDON{dagger}, A. P. MUKHERJEE*, and P. R. READ{ddagger}

*Chesterton Hospital Cambridge
{dagger}New Addenbrooke's Hospital Cambridge
{ddagger}Hoechst Pharmaceuticals Hounslow

A pilot study was carried out to compare the effect of ethacrynic acid and frusemide on glucose tolerance in ten elderly inpatients, who were suffering from hemiparesis. One subject had to be withdrawn. None was seriously ill, was previously known to be diabetic, or was taking a diuretic.

The mean of two base-line glucose tolerance tests was compared with those after 14 days on one diuretic, after a further 11 days without a diuretic and after another 14 days period on the other diuretic. The values taken for comparison were the peak and two-hour sugar levels. No evidence emerged that either drug was inevitably diabetogenic in the short term, and indeed, if anything, they both appeared to possess slight anti-diabetic activity. The effect on carbohydrate metabolism is probably not a factor that needs to be taken into consideration when prescribing these drugs, but should hyperglycaemia develop during treatment, a change of diuretic is recommended.

The glucose tolerance test was found to be more reproducible than anticipated, possibly due to the controlled circumstances.

If the two-hour blood sugar is taken as the criterion, most elderly subjects showed evidence of impaired glucose tolerance.


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