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Age and Ageing 2001; 30: 391-393
© 2001, British Geriatrics Society

Research papers

Drug absorption may be delayed after stroke: results of the paracetamol absorption test

Peter Crome1,, Mazen Rizeq3, Steve George4, Robin A. Braithwaite4 and Peter W. Jones2

1 School of Postgraduate Medicine, University of Keele, Thornburrow Drive, Hartshill, Stoke on Trent ST4 7QB, UK
2 Department of Mathematics, Keele University, Keele, Staffordshire, UK
3 North Staffordshire Combined Healthcare NHS Trust, City General Hospital, Stoke-on-Trent, UK
4 Regional Laboratory for Toxicology, City Hospital NHS Trust (Teaching), Birmingham, UK

Abstract

Background: autonomic changes are frequent after stroke but it is not known whether gastric emptying is altered. We have investigated this using the paracetamol absorption test.

Methods: 12 acute stroke patients and 13 healthy controls of similar age received 1 g oral paracetamol tablets. We studied all patients within 24 h of the stroke and 5 days later. Standard pharmacokinetic measurements were derived from the plasma paracetamol–time curve.

Results: in acute stroke patients, mean plasma Tmax was delayed compared with that in controls (96.3 vs 46.2 min, P=0.015). The Cmax of paracetamol was also lower (16.1 vs 23.9 mg l-1, P=0.028). The area under the curve of paracetamol did not differ significantly in acute stroke patients and controls.

Conclusions: gastric emptying appears to be delayed in acute stroke patients, and this may result in delayed pharmacological action of orally administered drugs.

Keywords: drug absorption, gastric emptying, paracetamol, stroke


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