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Age and Ageing 2002; 31: 307-309
© 2002, British Geriatrics Society

Case reports

An N-of-1 randomized controlled trial (‘N-of-1 trial’) of donepezil in the treatment of non-progressive amnestic syndrome

James D. Price and John Grimley Evans

Division of Clinical Geratology, Nuffield Department of Clinical Medicine, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK

Introduction: a professional man sustained a residual, persisting, isolated impairment of short-term memory secondary to severe carbon monoxide poisoning. Informal, open trial of the cholinesterase inhibitor donepezil resulted in uncertain benefit.

Protocol: an N-of-1 randomized, double-blind controlled trial of donepezil against placebo. Placebo-induced headache permitted evaluation of donepezil at only the 5 mg dose.

Results: there was no improvement in short-term memory.

Conclusion: the trial excluded significant benefit of donepezil 5 mg in this patient, preventing long-term unnecessary prescription. Beneficial effects in other similar patients or at higher dosage cannot be excluded.

Keywords: randomized controlled trials, cholinesterase-inhibitors, drug therapy, amnesia


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