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Age and Ageing 2002; 31: 440-444
© 2002, British Geriatrics Society

Research paper

Minimal hippocampal width relates to plasma homocysteine in community-dwelling older people

Jonathan H. Williams, Erlick A. C. Pereira, Marc M. Budge and Kevin M. Bradley

Oxford Project to Investigate Memory and Ageing (OPTIMA), Department of Pharmacology, University of Oxford and Radcliffe Infirmary Trust, Woodstock Road, Oxford OX2 6HE, UK

Abstract

Background: the hippocampus is important for memory. Hippocampal atrophy and higher levels of homocysteine may both predict cognitive dysfunction in community-dwelling older people. We tested if higher homocysteine relates to hippocampal thinning in this group.

Subjects: 156 community-dwelling volunteers without clinical memory problems.

Method: we measured minimal hippocampal widths on magnetic resonance images and homocysteine in plasma.

Results: minimal hippocampal widths related inversely to homocysteine levels.

Conclusions: our results indicate that, even in healthy older people, homocysteine may damage the hippocampus. Reducing homocysteine levels in healthy older people may help to prevent Alzheimer's disease.

Keywords: ageing, hippocampus, homocysteine, magnetic resonance imaging, body mass index


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