Age and Ageing 2003; 32: 475-483
© 2003, British Geriatrics Society
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Antipsychotic prescribing in older people
1 Specialist Registrar in Old Age Psychiatry, Bradford Community Health NHS Trust, Lynfield Mount Hospital, Bradford, UK
2 Visiting Professor of Old Age Psychiatry, School of Human and Health Sciences, University of Huddersfield, Huddersfield, UK
3 Consultant in Old Age Psychiatry, South West Yorkshire Mental Health NHS Trust, Fieldhead Hospital, Wakefield, Yorkshire, UK
4 Consultant in Old Age Psychiatry, South West Yorkshire Mental Health NHS Trust, St Luke’s Hospital, Huddersfield, UK
Address correspondence to: S. Curran. Ageing and Mental Health Research Group, Room R1/13, Ramsden Building, School of Human and Health Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DK, UK. Fax: (+44) 1484 473760. Email: s.curran{at}hud.ac.uk
Antipsychotic medications have made a significant contribution to the care of the mentally ill people over the past 50 years, with good evidence that both typical and atypical agents are effective in the treatment of schizophrenia and related conditions. In addition they are widely used to good effect in other disorders including psychotic depression, dementia and delirium. Both typical and atypical agents may cause severe side-effects and, in the elderly in particular, there is an increased propensity for drug interactions. If used with care, antipsychotics are usually well tolerated, especially the atypical drugs.
Although antipsychotics are effective at reducing psychotic symptoms their limitations should be recognised. They do not ‘cure’ the underlying illness, and the management of psychotic and behavioural symptoms must take into consideration treatment of physical illness as well as psychosocial interventions. In addition, the antipsychotic effect may take one to two weeks to be evident so doses should not be increased too rapidly. Often small doses are effective in the elderly if they are given sufficient time to work.
As our understanding of the mechanisms of psychosis improves it is hoped that new drugs will be developed with novel mechanisms of action with improved efficacy and reduced side-effects. There are several drugs in development, some sharing similarities to currently available agents whilst others have novel mechanisms of actions involving glutamate and nicotinic receptors. Pharmacogenetics is also likely to be increasingly important over the next few years. As the genetic basis of many psychiatric disorders becomes more clearly established it is likely that drugs specifically designed for particular sub-groups of receptors will be developed.
Finally, although the pharmacological treatment of psychotic disorders in younger people has been given considerable attention, there is a paucity of good quality research on antipsychotic drug use in older people. There is a need to redress this balance to ensure that the prescribing of antipsychotics in older people is evidence based.
Keywords: antipsychotics, psychiatry, older people
Received April 19, 2002; Revision received February 12, 2003. accepted in revised form February 12, 2003.
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