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Age and Ageing Advance Access originally published online on July 22, 2004
Age and Ageing 2004 33(5):509-510; doi:10.1093/ageing/afh148
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Age and Aging Vol. 33 No. 5 © British Geriatrics Society 2004; all rights reserved

Case Report

Hydrochlorothiazide induced hepato-cholestatic liver injury

Zeev Arinzon1,2,*, Peisakh Alexander3 and Yitshal Berner2

1 Meuhedet Health Care System, Netania, Israel
2 Meir Hospital, Department of Geriatric Medicine, Kfar Saba, Israel and the Sackler School of Medicine, Tel Aviv University, Israel
3 Meuhedet Health Care System, Hadera, Israel

Address correspondence to: Z. Arinzon. Email: arinzon{at}walla.co.il

Hydrochlorothiazide and other thiazide-like diuretics are considered as a first-line drug for initial therapy in uncomplicated arterial hypertension [1]. There are several reports [2–6] of thiazide-induced cholecystitis, but here we report a case of serious hepatotoxicity associated with hydrochlorothiazide treatment.

Keywords: hydrochlorothiazide, side-effects, liver injury, cholestasis

Received February 12, 2004; accepted in revised form February 24, 2004.


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