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Age and Ageing Advance Access originally published online on August 12, 2004
Age and Ageing 2004 33(6):538-544; doi:10.1093/ageing/afh175
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Age and Ageing Vol. 33 No. 6 © British Geriatrics Society 2004; all rights reserved

Review

Calcific aortic stenosis: same old story?

S.Joanna Cowell1, David E. Newby2, Nicholas A. Boon1 and Andrew T. Elder3

1 Department of Cardiology, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SA, UK
2 Chancellor's Building, Royal Infirmary, 49 Little France Crescent, Edinburgh EH16 4SB, UK
3 Department of Medicine for the Elderly, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK

Address correspondence to: S. J. Cowell. Fax: (+44) 131 242 6422. Email: jo.cowell{at}ed.ac.uk

Calcific aortic stenosis is the commonest adult valvular heart condition seen in the western world. Its prevalence is continuing to rise, with predominance in older patients who are frequently undergoing successful aortic valve replacement. This review discusses the natural history of calcific aortic stenosis, highlights recent insights into its pathogenesis, and outlines current medical and surgical management. The potential role of novel therapeutic interventional strategies is discussed.

Keywords: aortic stenosis, aetiology, pathogenesis, management, medical therapy, elderly

Received September 17, 2003; accepted in revised form April 8, 2004.


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