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Age and Ageing 2005 34(2):190-193; doi:10.1093/ageing/afi017
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Age and Ageing Vol. 34 No. 2 © British Geriatrics Society 2005; all rights reserved

Case Report

Paraneoplastic limbic encephalitis—case report and review of literature

Sunil K. Munshi1, Bhomraj Thanvi2, Su Kiun Chin3, Irene Hubbard4, Alan Fletcher5 and Tony R. Vallance2

1 Department of Cerebrovascular Medicine & Medicine for the Elderly, Leicester General Hospital, University Hospital of Leicester, Gwendolen Road, Leicester LE5 4PW, UK
2 Department of Medicine for the Elderly, Leicester Royal Infirmary, Leicester LE1 5WW, UK
3 Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
4 Department of Medicine, Kettering General Hospital, Kettering, Northamptonshire, UK
5 Department of Pathology, Leicester Royal Infirmary, Leicester LE1 5WW, UK

Address correspondence to: S. K. Munshi. Email: sunil.munshi{at}uhl-tr.nhs.uk

We report a 77-year old man who presented with a sub-acute dementia associated with aggressive behaviour, ataxia, rapid progression and death. No cause for his illness could be detected in his lifetime, but at post mortem he was found to have paraneoplastic limbic encephalitis and a bronchogenic tumour. A diagnosis of paraneoplastic limbic encephalitis should be considered in the differential diagnosis of unexplained dementias and appropriate investigations performed to diagnose the condition.

Keywords: dementia, paraneoplastic syndrome, limbic encephalitis, elderly

Received July 3, 2004; Revision received November 3, 2004. accepted in revised form November 3, 2004.


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