Systematic Review |
A systematic review of prevalence and incidence studies of dementia with Lewy bodies
1 Department of Public Health and Primary Care, University of Cambridge, Robinson Way, Cambridge CB2 2SR, UK
2 Department of Psychiatry, Royal Liverpool University Hospital, Liverpool L69 3GA, UK
Address correspondence to: J. Zaccai. Fax: (+44) 330 330. E-mail: jhz21{at}cam.ac.uk
Background: substantial variation in the prevalence of Dementia with Lewy Bodies (DLB) has been reported with estimates ranging from 0 to 26.3% of all dementia cases, potentially making it the second most common dementia subtype.
Objectives: the aim of this study was to review systematically and critically for the first time previous studies of the clinical prevalence and incidence of DLB in the population.
Methods: a systematic literature search was performed using PubMed. Selected articles had to describe an original study that provided a prevalence and/or incidence number for the whole population for DLB as defined by pre-set clinical criteria and findings.
Results: six studies reporting the prevalence of DLB and one study reporting the incidence of DLB met the inclusion criteria. Prevalence estimates, depending on case criteria, range from 0 to 5% with regard to the general population, and from 0 to 30.5% of all dementia cases. The only estimate for DLB incidence is 0.1% a year for the general population and 3.2% a year for all new dementia cases. The number of available studies was too small to hypothesise on the potential effect of age, sex and genetic background on the results.
Conclusions: although the literature on the prevalence and incidence of DLB is limited, there is a general consensus that DLB must be considered in the range of neurodegenerative conditions in the elderly. The move towards use of consensus criteria facilitates comparison and is welcome. Their application in a more routine way towards rigorously defined and selected study populations will lead to more comparable and generalisable studies in the future.
Keywords: dementia with Lewy bodies, Parkinson’s disease dementia, prevalence, incidence, population, elderly
Received May 24, 2005; accepted in revised form August 17, 2005.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Y Matsui, Y Tanizaki, H Arima, K Yonemoto, Y Doi, T Ninomiya, K Sasaki, M Iida, T Iwaki, S Kanba, et al. Incidence and survival of dementia in a general population of Japanese elderly: the Hisayama study J. Neurol. Neurosurg. Psychiatry, April 1, 2009; 80(4): 366 - 370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. DelleDonne, K. J. Klos, H. Fujishiro, Z. Ahmed, J. E. Parisi, K. A. Josephs, R. Frigerio, M. Burnett, Z. K. Wszolek, R. J. Uitti, et al. Incidental Lewy Body Disease and Preclinical Parkinson Disease Arch Neurol, August 1, 2008; 65(8): 1074 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Roks, E S C Korf, W M van der Flier, P Scheltens, and C J Stam The use of EEG in the diagnosis of dementia with Lewy bodies J. Neurol. Neurosurg. Psychiatry, April 1, 2008; 79(4): 377 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. M. Brust A 74-Year-Old Man With Memory Loss and Neuropathy Who Enjoys Alcoholic Beverages JAMA, March 5, 2008; 299(9): 1046 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Thomas, U Hestermann, S Walther, U Pfueller, M Hack, P Oster, C Mundt, and M Weisbrod Prolonged activation EEG differentiates dementia with and without delirium in frail elderly patients J. Neurol. Neurosurg. Psychiatry, February 1, 2008; 79(2): 119 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Andersson, E. H. Wiig, L. Minthon, and E. Londos A Quick Test for Cognitive Speed: A Measure of Cognitive Speed in Dementia With Lewy Bodies American Journal of Alzheimer's Disease and Other Dementias, September 1, 2007; 22(4): 313 - 318. [Abstract] [PDF]
|
|
|
|
 |
|
 V. Bogaerts, S. Engelborghs, S. Kumar-Singh, D. Goossens, B. Pickut, J. van der Zee, K. Sleegers, K. Peeters, J.-J. Martin, J. Del-Favero, et al. A novel locus for dementia with Lewy bodies: a clinically and genetically heterogeneous disorder Brain, September 1, 2007; 130(9): 2277 - 2291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Whitwell, S. D. Weigand, M. M. Shiung, B. F. Boeve, T. J. Ferman, G. E. Smith, D. S. Knopman, R. C. Petersen, E. E. Benarroch, K. A. Josephs, et al. Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's disease Brain, March 1, 2007; 130(3): 708 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Tschanz, K. A. Welsh-Bohmer, C. G. Lyketsos, C. Corcoran, R. C. Green, K. Hayden, M. C. Norton, P. P. Zandi, L. Toone, N. A. West, et al. Conversion to dementia from mild cognitive disorder: the Cache County Study. Neurology, July 25, 2006; 67(2): 229 - 234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Jenner and C. W. Olanow The pathogenesis of cell death in Parkinson's disease Neurology, May 23, 2006; 66(10_suppl_4): S24 - S36. [Abstract] [Full Text]
|
|